The 27-year-old former England rugby union international retired from the sport last year to pursue a career in the NFL.
Wade, who was released by Wasps in October, knew he was taking a risk in changing sports.
The former rugby winger is seen as a possible running back and was selected by the Bills as part of the NFL’s International Player Pathway programme.
Wade hopes he can learn from veteran backs Frank Gore and LeSean McCoy to help him through the Bills training camp.
“I’ll be looking to those guys but also the other veterans to learn how to survive in the NFL, to learn more about the game and how to apply yourself, Wade said.
“These guys have been there and done it so there is no one better to learn from.”
When asked about what his message is to Bills fans, Wade said: ”I know that they are an extremely passionate group and that there is bound to be a lot of table jumping.
“I love it and can’t wait to see how they do things out there, get stuck into the culture and learn as much about Buffalo as possible.
“I can’t wait to get over there now.”
Wade, who won one cap for England in 2013 and was selected for the British and Irish Lions squad the same summer, is third in the all-time Premiership try-scorers list with 82.
He said Buffalo’s General Manager, Brandon Beane, was excited about working with him after watching some of his rugby clips and his Pro Day.
“He was really excited,” Wade added.
“He doesn’t know a huge amount about rugby but has watched several clips from my rugby days.
“More importantly, however, he watched my Pro Day and has seen me training and was impressed with everything he saw. We can’t wait to start working together.
“We are still yet to meet in person so obviously that is the next step.”
The IPP will give Wade an opportunity to train with the Bills in an attempt to earn a place on their roster.
However, if he doesn’t make Buffalo’s 53-man roster, it’s likely he will be placed in the Bill’s practice squad.
“We are only 15 weeks from finding out if we have made the final roster,” Wade said.
“However, it’s been such a difficult road to get this far that I’m very thankful.
“I owe a lot to the people who have helped me get this far.”